The science of caffeine and paracetamol

Paracetamol exerts its analgesic and antipyretic effect by inhibition of prostaglandins.1 On the other hand, the antagonism of adenosine receptors and inhibition of cyclo-oxygenase activity at some sites may explain caffeine’s adjuvant properties.2,3


Release tough pain with Panadol Extra.

Panadol Extra provides up to 37% more powerful pain relief than standard paracetamol

Discover the Panadol range with paracetamol and caffeine

Panadol Extra with caffeine and paracetamol pack shot

Panadol Extra

With a dual “active” formulation that fights tough pains such as headaches,4,5 migraines,6 dental pain7 and menstrual pain.8

Panadol Migraine with caffeine, paracetamol and aspirin pack shot

Panadol Migraine

A powerful over-the counter triple action analgesic containing paracetamol, acetylsalicylic acid (aspirin) and caffeine that targets major symptoms (photophobia, phonophobia, nausea and pain) of migraine with or without aura.9

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Woman with migraine

Headaches and migraines

Learn more about headaches and migraines.

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Mechanism of migraine

A new dimension in migraine therapy

Go in-depth into the problem of migraine and its management.

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Patient relieved from migraine pain

Customer care for pharmacists

Specially tailored for pharmacists, discover in depth information on how to manage your migraine patients

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