Panadol Overview

Man experiencing pain relief after using Panadol products

Panadol is the No.1 pain relief brand* with 65 years of experience and expertise and is trusted by millions of consumers and HCPs in pain and fever.1

Panadol in pain relief

Happy people in a crowd


Globally, paracetamol or acetaminophen is one of the most used analgesic and antipyretic over-the-counter drugs.2,3

Man in pain at desk holding his neck

Panadol for pain relief

Paracetamol is currently formulated as a single compound or as an active ingredient of multi-component preparations in combination with active ingredients4 to provide relief from fever and different types of pain (e.g. muscular and joint pains, headaches and migraines, and dysmenorrhoea).

Woman taking a Panadol paracetamol product for pain relief

Panadol’s suitability

Paracetamol, the active ingredient in Panadol, is suitable for 98% of the population,5 and is recommended across a broad range of patients including those with cardiovascular disease, dengue fever and COVID-19.6–12 Panadol can be taken on an empty stomach, due to its favourable GI tolerability vs NSAIDs.13

In children, paracetamol’s GI tolerability is the same vs NSAIDs, with fewer drug-drug interactions than NSAIDs.14,15

Innovative technology

  • Optizorb technology

    Optizorb formulation icon

    Optizorb technology contains three main ingredients which are alginic acid, calcium carbonate and crospovidone that help speed the breakdown of paracetamol tablets in the stomach.16,17

    Learn more

  • Revolutionary bi-layer technology

    Bi-layer technology

    Panadol has a unique bi-layer technology that uses two formulations – an immediate release layer on the outside of the caplet and a second underlying layer that delivers the remaining paracetamol for up to 8 hours of pain relief.18

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  • Paracetamol with caffeine

    Paracetamol and caffeine blocking pain receptors

    Panadol Extra contains caffeine, which acts as an analgesic adjuvant, by disrupting normal adenosine signaling by competitive inhibition. This in turn may contribute to or enhance the efficacy of other analgesics.19

    Learn more


The Panadol range includes products with innovative technology and in combination with other ingredients such as caffeine manages mild to moderate pain.

Panadol offers a range of solutions for individual patient needs

Panadol Advance with 500mg paracetamol pack shot

Panadol Advance

Panadol Advance has five times faster disintegration and dissolution† and two times better absorption than standard paracetamol.20

Panadol Extra with 500mg paracetamol and 65mg caffeine pack shot

Panadol Extra

Dual “active” formulation that fights tough pains.24-28

Panadol for children pack shot

Panadol for children

Panadol for children contains paracetamol, which is recommended as first-line treatment for fever and mild-to-moderate pain in children.17-19

Panadol Joint with 665mg paracetamol pack shot

Panadol Joint

Immediate and controlled paracetamol release for extended pain relief for up to 8 hours.32,33

Panadol Migraine with paracetamol, caffeine and aspirin pack shot

Panadol Migraine

The powerful triple action of paracetamol, acetylsalicylic acid (aspirin) and caffeine working together to help combat migraine symptoms.34,35

Panadol in practice

Grey-haired man smiling and walking with a stick

Joint pain & osteoarthritis

Based on the 2018 Global Pain Index (GPI), 92% of 24,000 people surveyed around the world suffered from some pain and 87% experienced joint pain.36 Discover more about joint and osteoarthritic pain including signs and symptoms and, how to manage them.

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Mother checking child for fever with a thermometer


Fever is a common sign and symptom observed in a variety of clinical settings.37 Discover more about fever in adults and children including how to assess fever, “red flag” symptoms and its management.

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Woman touching her forehead in pain with a headache

Headache disorders

Headache disorders, characterised by recurrent episode of headaches, are one of the most common disorders of the nervous system and, can be painful and disabling to sufferers.38 Find out more about tension-type headaches and migraines, “red flag” symptoms and how to manage them.

Learn more